Usability 
Founded in 1869, Nature is one of the most respected scientific journals in the world. It publishes original research from all branches of science as well editorials, book reviews and feature articles of interest to the scientific community.
Nature's desktop website got a "responsive design" makeover recently and now adapts itself to mobile viewport widths. Nature seems to expect mobile users to view the site in landscape orientation. The site's layout looked rather jumbled to me in portrait using the Android Gingerbread, Symbian Belle, Opera Mini and Opera Mobile browsers.